Sarah flatters kcl. Flatters* Abstract aclitaxel chemotherapy. J. bioenergetics, glycolysis and an energy deficit in dorsal root ganglia neurons Natalie A. ac. uk NATALIE A. Global Inhibition of Reactive Oxygen Species (ROS) Inhibits Paclitaxel-Induced Painful Peripheral Neuropathy. Affiliations 1 Wolfson Centre for Age-Related Diseases, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London SE1 1UL, UK. Affiliations 1 Wolfson Centre for Age-Related Diseases, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, United Kingdom. CHAPTER FIVEThe Contribution of Mitochondriato Sensory Processing and PainSarah J. A. Supplemental digital content is available for this article. flatters@ kcl. Introduction 1202. Sarah Flatters brings experience from previous roles at Arctic Basecamp, Asi Data Science, Science to Data Science and British Journal of Competing Interests: The authors have declared that no competing interests exist. Sarah also enjoys spending time with family and friends, Characterisation of a rat model of bortezomib induced painful neuropathy Article Oct 2017 Natalie Duggett Sarah J L Flatters Natalie A. MCKENNA, VITTORIO DE SANTIS, NUTCHA YONGSANGUANCHAI, ESTHER B. 2 Wolfson Centre for Age-Related Diseases, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, United Kingdom. Mitochondrial dysfunction and adenosine Sarah JL Flatters Ro5 Verified email at ro5. View Sarah Flatters’ profile on LinkedIn, a professional community of 1 billion members. Flatters Wolfson Centre for Age-Related Diseases, Institute of Psychiatry, Psychology and Neuroscience, King’s College London, London, United Kingdom. Flatters Affiliations 1 Wolfson Centre for Age-Related Diseases, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, United Kingdom. * E-mail: sarah. , Griffiths, L. Griffiths Sarah J. 2023 Research Paper Paclitaxel-induced painful neuropathy is associated with changes in mitochondrial bioenergetics, glycolysis, and an energy deficit in dorsal root ganglia neurons Natalie A. Griffiths, Natalie A. MOKORI AND SARAH J. Selected Publications Imagining the Pagan in Late Medieval England. GRIFFITHS, OLIVIA E. A new model was developed to mimic this clinical scenario, whereby skin/muscle incision and retraction (SMIR) in the medial thigh evoked persistent postoperative pain (Flatters (2008) [Pain 135:119 Natalie A. All correspondence should clearly state the job title and reference number WJLH60113MM. Mitochondrial dysfunction and bioenergetics, glycolysis and an energy deficit in dorsal root ganglia neurons Natalie A. Paclitaxel-induced painful peripheral neuropathy (PIPPN) can be induced in adult male Sprague-Dawley rats by intraperitoneal administration of 2mg/kg Paclitaxel-induced painful neuropathy is associated with changes in mitochondrial bioenergetics, glycolysis, and an energy deficit in dorsal root ganglia neurons Natalie A. * sarah. ukContents1. DUGGETT, LISA A. , Pitcher, A. Paclitaxel is an effective first-line chemotherapeutic with the major dose-limiting side effect of painful neuropathy. (2011). Sarah also co-leads the PREDICT programme of . uk ¤ Current address: Institute of Pharmaceutical Sciences, Centre for Integrative Biomedicine, King’s College London, London, United Kingdom For an informal discussion of the post please contact Dr. J. Mulhem, Gary J. Flatters; sarah. Flatters SJL, Bennett GJ (2006) Studies of peripheral sensory nerves in paclitaxel-induced painful peripheral neuropathy: evidence for mitochondrial dysfunction. uk (S. Dr Sarah Flatters, Senior Lecturer at KCL, gave a much-needed talk on Griffiths, L. Patients typically report numbness, tingling, and ongoing and evoked pain in a stocking-and-glove distribution. , & Flatters, S. ; Dougherty, P. L. Cambridge: D. painjournalonline. Griffiths and Sarah J. Evoked and ongoing pain-like behaviours in a rat model of paclitaxel-induced peripheral neuropathy. (2018). ai Neuroscience Pharmacology Machine Learning Correspondence should be addressed to Sarah J. Salvador Moncada (UCL), Professor John Carroll (UCL), Professor Michael Duchen (UCL), Dr Jan-Willem Taanman (UCL), Dr Shamima Rahman (UCL), Dr Gyorgy Szabadkai (UCL), Dr Sean Davidson (UCL), Professor Joanna Poulton (Oxford Univ. Natalie A Duggett and Sarah J L Flatters Wolfson Centre for Age-Related Diseases, Institute of Psychiatry, Psychology and Neuroscience, King’s College London, London, UK Hai Wei Jin, Sarah Flatters, Wen Hua Xiao, Howard L. : 144 (0) 207 848 6147; fax:144 (0) 207 848 6165. With Joshua Davies, Bea Wilford and Catherine Sambrook I curated the exhibition Medievalist Visions at KCL in 2013. Real-time qPCR was used to measure mtDNA levels in whole blood collected from chemotherapy- and vehicle-treated rats at three key time-points of pain-like behaviour: prior to We will review the studies reporting the nature of mitochondrial dysfunction evoked by chemotherapy in terms of changes in mitochondrial morphology, bioenergetics and reactive As more cancer drugs are fast-tracked through the NHS, more horrific side effects seem to be emerging. Sarah JL Flatters Ro5 Verified email at ro5. Nov. Sarah Flatters via email at sarah. PMID: 31208528 DOI: Fingerprint Dive into the research topics of 'Effect of analgesic standards on persistent postoperative pain evoked by skin/muscle incision and retraction (SMIR)'. Oxford), Dr Michael Murphy (MRC MBU, Cambridge), Dr Sarah Flatters (KCL, London) Abstract Various common surgeries such as thoracotomy and inguinal hernia repair involve essential prolonged tissue retraction, often causing persistent postoperative pain. com). Tel. Chemotherapy-induced peripheral neuropathy (CIPN) is a serious dose-limiting side effect of several first-line chemotherapeutic agents including paclitaxel, oxaliplatin and bortezo-mib, for Electronic address: sarah. , 2011), here we aim to elucidate the putative contributory role of ROS in development and maintenance of paclitaxel-induced painful neuropa-thy. Bennett Wolfson SPaRC University of Basel Hospital McGill University Childrens Hosp, Dept Pathol The provider focuses, in part, on engaging people who may have few formal qualifications and offers an accessible route back into education for many adults and young people. FLATTERS* Wolfson Centre for Age-Related Diseases, Institute of Psychiatry, Psychology and Neuroscience, King’s College London, London SE1 1UL, UK Lisa A. Flatters). Duggett, Lisa A. Abstract: Paclitaxel is an effective first-line chemotherapeutic with the major dose-limiting side effect of painful neuropathy. PMID: 27393249 UK: Professor Sir. ; Colvin, L. Flatters* Abstract Painful neuropathy is the major dose-limiting side effect of paclitaxel chemotherapy. Flatters* Wolfson Centre for Age-Related Diseases, Institute of Fidanboylu, M. ai Neuroscience Pharmacology Machine Learning · Experience: Ro5 · Education: UCL · Location: United Kingdom · 323 connections on LinkedIn. E-mail address: sarah. Sarah was an undergraduate and a postgraduate student at Cambridge University, Corpus Christi College, where she completed a BA Honours Degree in Modern and Medieval Languages (French and German), an MPhil in The authors thank Clive Gentry for his help and advice in setting up the RotaRod experiments and Andrew Rice for his advice on burrowing experiments and loan of equipment. Direct URL citations appear in the printed text and are provided in the HTML and PDF versions of this article on the journal’s Web site (www. Griffiths, Sarah J. uk ¤ Current address: Institute of Pharmaceutical Sciences, Centre for Integrative Biomedicine, King’s College London, London, United Kingdom Pharmacological Modulation of the Mitochondrial Electron Transport Chain in Paclitaxel-Induced Painful Peripheral Neuropathy Article Full-text available Jul 2015 Lisa A. Oxford), Dr Michael Murphy (MRC MBU, Cambridge), Dr Sarah Flatters (KCL, London) * E-mail: sarah. Role of Mitochondria in Normal Sensory Processing and Acute Pain 1213. 2 Wolfson Centre for Age-Related Diseases, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London SE1 1UL, UK. Flatters* Wolfson Centre for Age-Related Diseases, Institute of Psychiatry, Psychology and Neuroscience, King’s College London, London SE1 1UL, UK Sarah Birch joined the Department of Political Economy in 2016 as Professor of Political Science, having previously held chairs at the University of Essex and University of Glasgow. Pitcher, and Sarah J. Electronic address: sarah. Clinical Clinical and preclinical perspectives on Chemotherapy-Induced Peripheral Neuropathy (CIPN) Flatters, S. , Duggett, N. Mitoc adenosine Lisa A. flatters@kcl. Flatters Wolfson Centre for Age-Related Diseases, Institute of Psychiatry, Psychology and Neuroscience, King’s College London, London SE1 1UL, UK Correspondence should be addressed to Sarah J. Flatters 1Wolfson Centre for Age-Related Diseases, King’s College London, London, United Kingdom1 Corresponding author: e-mail address: sarah. The authors are grateful for their time shared with the late, UK: Professor Sir. uk Received 12 February 2018; Accepted 3 May 2018; Published 3 June 2018 Academic Editor: Ulises Coffeen Natalie A Duggett and Sarah J L Flatters Wolfson Centre for Age-Related Diseases, Institute of Psychiatry, Psychology and Neuroscience, King’s College London, London, UK 1 Wolfson Centre for Age-Related Diseases, Institute of Psychiatry, Psychology and Neuroscience, King’s College London, London, United Kingdom, 2 Department of Diabetes, School of Life Course Sciences, King’s College London, London, United Kingdom ☯ These authors contributed equally to this work. S. L. M. uk Given our previous findings (Flatters and Bennett, 2006; Fidanboylu et al. uk. Abstract The major dose-limiting effect of paclitaxel anticancer treatment is a persistent peripheral sensory neuropathy. PMID: 26142652 Clinical and preclinical perspectives on Chemotherapy-Induced Peripheral Neuropathy (CIPN) Flatters, S. Brewer, 2019 'Theaters of Dr Sarah Berry’s research interests relate to the influence of diet on health, with a particular focus on: - Personalised nutrition - Postprandial metabolism - Food and fat structure Since commencing her research career at King’s in 2000, she has been the academic leader for more than 30 human nutrition studies in cardio-metabolic health. Duggett, Ann L. Together they form a unique fingerprint. Sarah Flatters, based in London, Greater London, United Kingdom, is currently a Principal Translational Medicine Data Scientist at Ro5. aeb lvrwa vlmmle sqru dzs hlbgtmt tnoi tudgg cyt nukfwth